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Similarly, Vargiu et al

Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120

(E) After matrix detachment, anoikis-resistant cancer cells decrease intracellular ROS levels through inducing enzymes involved in the glycolysis and antioxidant systems for their survival

Fluorescence intensity was measured on the FITC channel using the Beckman Coulter MoFlo Astrios

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization