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Acetaminophen metabolism and production of toxic metabolite (Courtesy Download Scientific Diagram Paracetamol toxicity Deranged Physiology A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem
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