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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

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These previous findings, strongly supporting our approach to study the inter-molecular interactions at nano bio interface

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Using a 50% probability cutoff, the AHEAD Score achieved a specificity of 61.5% (107 out of 174 non-cases correctly identified) and a sensitivity of 63.3% (19 out of 30 cases correctly identified)