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Figure 3 Gut microbiota and metabolites participate in the development of biliary atresia by regulating inflammation Inflammatory response plays an essential role in the development of BA

Upregulation of Nrf2 initiates transcription of antioxidant protein genes and iron metabolism protein genes, thereby inhibiting ferroptosis (Sun et al., 2016)

Elife 3 , e02028 (2014)

In the future, rather than look for additional global markers of astrogliosis, it will likely be more useful to look for molecules upregulated by astrocytes in specific contexts and that are associated with specific functions or effects of astrogliosis