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[PMID: 16403733] [47] Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E

10.1038/nrn1726 Nat

These studies do not represent approved clinical applications and are provided for research reference purposes only

Earlier recommendations advocated treatment of the cobalamin C defect with a combined approach that utilizes vitamin B12 plus betaine to provide a substrate for the conversion of homocysteine into methionine through betaine-homocysteine methyltransferase, and folic acid to enhance the remethylation pathway (164)