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AI in the pharmaceutical Drug discovery has historically relied heavily on serendipity, with many significant breakthroughs occurring through chance observations or unintended findings [80]

Evidence Evidence that CFS/ME patients are low in methylation cycle metabolites: B vitamin evidence In a small study of 58 chronic fatigue syndrome patients with a history of Epstein-Barr infection and B-cell immunodeficiency, 81% responded to folinic acid

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In another study, up-regulation of ion channels including voltage-gated sodium channels, voltage-gated potassium channels (K v ) and TRPs were observed in both DRGs and spinal dorsal horns of paclitaxel-treated rats (Kim et al., 2020)