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In the paracellular route, analytes traverse the inter-endothelial junctions (IEJs), which permit the passage of small molecules - generally molecules smaller than ~70 kDa - through diffusion and advection [44]

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et al., 2023) the cAMP/PKA/p-CREB pathway was altered in the amygdala alongside neuronal apoptosis (Jiang et al., 2023), and cortical cytokinesincluding IL-1, IL-6, and TNF- were elevated (Wang J