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Pre-clinical studies using VitC in combination with chemotherapy and radiation therapy In pre-clinical models, high-dose VitC is reported to enhance the effectivity of a wide variety of chemotherapeutics such as carboplatin [63, 89], cisplatin [51, 89, 100,101,102,103, 179, 180], chlorambucil [181], 5-FU [88, 89, 182], gemcitabine [14, 110, 183, 184] and temozolomide [16, 54] in various cancer cell types, often in a synergistic manner or by enhancing treatment efficacy (Table 1 and Fig

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