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Studies have shown that B cells also play a role in the progression of osteoarthritis (OA), as their proliferation and differentiation capabilities are altered in the synovium of OA patients ( Research indicates that B cells can secrete various pro-inflammatory factors, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-), which induce chondrocyte death and cartilage matrix destruction (126) ( Figure 4 )

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(2015), which highlighted the central role of GABAergic deficits in ASD-related social impairments

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