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OxPAPCs also trigger IL- 1 production through activation of the nod-like receptor protein 3 (NLRP3) inflammasome (Yeon et al

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The primary damaging effect is associated with a profound loss of astrocytic glutamate clearance, leading to excitotoxicity 246,247

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With extensive ongoing efforts to develop next-generation platinum compounds by identifying new targets and enhancing their pharmacological properties, it is likely that multi-targeted platinum drugs will reach the clinical stage in the near future