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Safety is not just about the molecule itself

For example, interference with CYP2D6 activity may influence tamoxifen bioactivation, potentially affecting therapeutic efficacy

DMRT transcription factors have been postulated as important determinants of sex differences (Casado-Navarro and Serrano-Saiz, 2022 )

In the context of colon cancer, high levels of YTHDF2 are associated with increased malignancy, as it enhances the expression and translation of mRNAs that drive cell proliferation and invasion