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Tirzepatide activates the following gut hormone receptors: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) This process reduces hunger while delaying food from getting to the small intestine

This allows for higher bioavailability and more efficient correction of deficiencies compared to oral supplements, particularly for individuals with absorption issues or significant deficiencies

It may promote tissue repair, support blood vessel growth, reduce inflammation, and aid muscle, tendon, and ligament recovery

Russ J Bioorganic Chem

Gastrointestinal disorders and surgeries Some GI-related conditions and surgeries may affect B12 absorption: Crohns disease: A chronic inflammatory disease, Crohns affects the small and large intestine particularly the distal ileum, which is where B12 is absorbed