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In particular, CD4 + T cell subsets can differentiate to produce a variety of pro-inflammatory cytokines and chemokines, which are involved in the pathogenesis of RA

For example, by upregulating the E3 ubiquitin ligase STUB1, which encourages GPX4 ubiquitination and associated destruction, sanguinarine affects ferroptosis [69]

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10.1016/j.bbcan.2014.07.011 Biochim

This formulation demonstrated a notable decrease in levels of TNF-, interleukin-17 and growth factor-, alongside enhanced levels of IL-10 effectively alleviating symptoms in a psoriasis mouse model