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Dietary thiamine restriction in rodents also decreases relative abundance of this family, which is accompanied by reduced fecal butyrate concentrations (61)

Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies

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Homa, James F