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The driver may be systemic or involve a different pathway, including mast-cell activation

This characteristic has made it a valuable research tool for studying transporter selectivity, ligand-transporter interactions, and comparative mechanisms of monoamine reuptake inhibition

In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway

Used medically for HIV-related lipodystrophy but sometimes taken off-label for fat loss

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