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Collectively, these studies provide evidence for the potential role of astrocyte senescence and dysfunction in eliciting neuroinflammation, neurotoxicity, neuronal hyperexcitability, and neurodegeneration in the aging brain

72 Previous Study has shown that SAH can reduce the expression of DNA methyltransferase DNMT1 protein, lead to demethylation of the CpG islands in the NF-B gene promoter region, and increase NF-B expression, trigger the expression of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, and thus induce cellular senescence in rat aortic smooth muscle cells

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They may also advise the individual on boosting their iron levels, for example, through dietary choices