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This process is intimately linked to ROS generation, as AGEs-RAGE interaction induces NADPH oxidase (NOX1, NOX4) expression, triggering sustained superoxide and H 2 O 2 production that further modifies ECM integrity (Yang et al., 2024

Nature 549:399403 Ko PJ, Dixon SJ (2018) Protein palmitoylation and cancer

In 9 h, 134 12 nanomoles of peptide and 705 84 nanomoles of copper permeated though the microneedle treated human skin, while almost no peptide or copper permeated through intact human skin

Most purification systems improve the cleanliness of tap water, especially in areas with lower water quality

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