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Biochem Biophys Res Commun 375:129133

Therefore, ROS can be considered physiological mediators of great importance in plasticity and signaling, but they can become detrimental to neuronal function when they accumulate excessively in the brain [74]

( b ) Metagene plot (mean) for H3K14ac signal at the LSD1 peaks ( 5 kb) across the 498 downregulated genes (top) and 498 unaffected control genes (bottom)

159,160 Given the aforementioned reactivity of 1,4-NQs in biological systems, it should not be surprising that 1,4-NQs have frequently been observed to induce marked perturbations of metabolism, including ROS production, thiol depletion, alkylation/arylation of numerous target proteins, DNA damage and genotoxicity in diverse biological systems