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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

Safety and effective usage come from medical supervision and adherence to prescribed doses

However, complete symptom resolution, particularly for neurological complications, may take several weeks to months depending on the severity and duration of deficiency before treatment

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They are not approved for human or animal consumption, or for any form of therapeutic or diagnostic use