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Cis -amminedichloro(2-methylpyridine) platinum (II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology and pharmacokinetics in mice

Standard Dosing Range: Low dose: 200 to 250 mcg once daily Moderate dose: 250 to 500 mcg once or twice daily Higher dose: 500 to 800 mcg once or twice daily Weight-Based Dosing: Based on animal study extrapolations, an estimated human equivalent dose is approximately 1.6 mcg/kg body weight, translating to roughly 110 mcg for a 150-pound person and 145 mcg for a 200-pound person when using oral administration

doi: 10.1080/23308249.2015.1112357 24 LiJ.LiangX.-F.TanQ.YuanX.LiuL.ZhouY

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