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Limulus Amebocyte Lysate (LAL) testing detects bacterial endotoxins that cause immune reactions - even when the compound looks completely clean

While in most cases, CB 1 receptor agonists induce phosphorylation of p38 MAPK in rat and mice hippocampi, THC exhibits varied effects on p38 activation, stimulating it in CHO cells but inhibiting it in the AF5 cell line, while cannabidiol suppresses p38 MAPK in PC12 cells

The STING agonist MnO 2 @OVA [98] can target both macrophages and DCs via mannose modification, thereby activating the cGAS-STING pathway in both cells

10.1038/s41419-020-03046-z 34 GuoL.LiangZ.YangL.DuW.YuT.TangH.et al (2021)

2b), while RFK mRNA levels were comparable in most patients (Supplementary Fig