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Furthermore, some pharmacological studies fail to report essential details such as minimal active concentrations, full dose-response relationships, the use of appropriate positive and negative controls, and proper characterization of the natural material used, including taxonomic validation and chemical standardization

14 revealed that the PMI and PTK hydrogels did not trigger obvious inflammatory reactions, and no inflammation cell accumulation was detected, which should be safe for in vivo applications

Systematic review and meta-analysis of microbiota-gut-astrocyte axis perturbation in neurodegeneration, brain injury, and mood disorders

This peptide also appeared to modulate immune cell behavior, with reports of increased macrophage activity, which may support resolution rather than persistence of inflammation