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A previous study revealed that TNF could enhance IFN responses by activating cGAS-STING signaling, thereby supporting the joint inflammation (57)

10.1007/s00280-019-03912-4 Cancer Chemother

A T/C polymorphism in the GPX4 3UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Conversely, a phase III trial (n = 759) showed improved PFS in mCRPC patients with high PD-L1(IC2/3) and CD8 + gene expression treated with enzalutamide plus atezolizumab, though OS benefits were not observed (Powles et al., 2022)