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Description

Overall, in the presence of the terminal electron acceptor -oxygen- glycolysis is slowed down because of phosphofructokinase-1 inhibition by citrate and ATP

Where did it happen

Sci Rep (2019) 9(1):19180

Given that these species can accumulate not only through increased production but also through decreased clearance, an inadequate antioxidant response, particularly associated with a dysregulation of NRF2 transcriptional activity, could explain their gradual accumulation