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Here's what doctors and scientists say about the trend

They found that, despite the lack of consistent study protocols, collagen supplementation may benefit both healthy individuals who exercise and those with joint pain

The mechanisms include weight loss reducing upper airway fat deposition, improved respiratory muscle tone with reduced adiposity, and possible direct effects on central respiratory control through GLP-1R in the brainstem

Knowledge Gaps and Scholarly Debates USP37 as an Alternative Target: Recent discovery of the CHK2-USP37-FOXO4 stability axis suggests that small-molecule inhibitors of USP37 (e.g., Dacarbazine) may offer a more pharmacologically drug-like route to achieving the same senolytic effect as the FOXO4-DRI peptide (PNAS, 2026)

Urokinase is an activator for matrix remodeling and is detectable in tissues suffering wound healing and liver regeneration