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Appetite Modulation Models : A specialized compound for observing long-term signaling impact on hunger-regulating pathways in cellular models

Take-home message: - Peptides and assorted experimental drugs, like TB-500 and MK-677, are being recommended by fitness influencers to grow bigger muscles, lose fat, and recover from injuries faster - These drugs, many of which are claimed to boost levels of growth hormone, were studied in rodents and very small groups of human volunteers before being abandoned for not being beneficial or for causing unacceptable side effects - They are banned by the World Anti-Doping Agency and appear to be illegal in Canada and the United States, but can be purchased online

Yen BL, Yen M-L, Hsu P-J, Liu K-J, Wang C-J, Bai C-H, Sytwu H-K

Brain Struct Funct 217:687718

Early-stage research suggests intranasal dihexa may achieve therapeutic CNS concentrations with minimal systemic exposure, potentially extending the effective half life at the target site (hippocampus) while reducing plasma half life