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Another study also reported that the use of CuO-NPs can affect hepatic, renal, cardiac, and neural organs by altering the structure and physiology of those organs due to increased production of oxidative stress

The fat loss mechanism is indirect: elevated GH shifts the body toward fat oxidation and lean mass preservation

GCH1/BH4 axis The GTP cyclohydrolase-1 (GCH1)/Tetrahydrobiopterin (BH4) axis was deemed to be another independent pathway in the regulation of ferroptosis in several recent studies which performed the genome-wide screen (93, 94)