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Exposure to LPS or palmitic acid (PA) altered ceramide and triacylglyceride pools and differentially regulated TREM2 expression, recapitulating aspects of DAM or neurodegenerative microglia (NAM) lipid phenotypes (221)

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evidence from transgenic mouse models

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The resulting capillary occlusion and ischemia further aggravate retinal damage while stimulating VEGF overexpression, which drives pathological neovascularization and increases the risk of vitreous hemorrhage and tractional retinal detachment in advanced DR (74)