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Investigational research into NMN supplementation in insulin-resistant individuals has examined effects on insulin sensitivity and muscle glucose uptake, with early findings warranting further controlled investigation

doi: 10.1016/j.jhep.2019.08.026 Kim YJ, Tsang T, Anderson GR, Posimo JM, Brady DC ( 2020 )

The identification of gene expression profiles associated with progression of human diabetic neuropathy

Frontiers in Immunology 11: 388

Private Insurance Coverage Most private insurance plans cover viscosupplementation when medical necessity criteria are met, typically requiring: Failed conservative treatment (usually 3-6 months) Radiographic evidence of osteoarthritis Prior authorization in most cases Step therapy requirements (trying other treatments first) Coverage varies by insurance carrier and specific plan, so always verify benefits before treatment