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The BAC- SNCA A53T/ mice can be used as a model of prodromal PD because they develop characteristic non-motor symptoms, such as rapid eye movement (REM) sleep behavior disorder at 5 months old and hyposmia at 9 months old despite presenting a mild age-dependent DA neurodegeneration phenotype

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Almost 90% of those with diabetes have type 2 DM, the most prevalent DM [79, 80] and causes chronically high blood glucose levels by reducing insulin secretion or activity

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doi: 10.1017/S0029665118002872 38 RoseS.MelnykS.PavlivO.BaiS.NickT