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It induces delta-wave sleep (NREM stage 3-4), the most restorative stage of sleep, by modulating circadian rhythms and the balance between inhibitory serotonin/GABA systems and activating pathways

[DOI] [PubMed] [Google Scholar] Stupnisek M, Franjic S, Drmic D, et al

However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)

Severe vitamin B12 deficiency in an exclusively breastfed 5-month-old Italian infant born to a mother receiving multivitamin supplementation during pregnancy. BMC pediatrics 12.1 (2012): 1-5