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The study found that within minutes of ketamine administration, the levels of Glu in the mPFC of MDD patients increased rapidly [100]

This is because tryptophan is an amino acid that is a precursor to both serotonin and melatonin, and is a key amino acid involved in sleep/wake circadian rhythms [24]

Krazeisen, A., Breitling, R., Moller, G., & Adamski, J

Dopamine neurons (DAns) in the substantia nigra pars compacta (SNPc) serve as key sites for the synthesis and storage of dopamine (DA) in the body, regulating human cognition and behavioral activity through the nigrostriatal pathway, midbrain limbic cortex system, nodular funnel system, and hypothalamic spinal tract

10.1016/j.bbrc.2009.03.004 Summary Keywords adipocytokines, airway remodeling, asthma, obesity, outcome Citation Listyoko AS, Okazaki R, Harada T, Inui G and Yamasaki A (2024) Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications