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"Targeting the STAT3 Signaling Pathway in Cancer: Role of Synthetic and Natural Inhibitors." Biochimica Et Biophysica Acta (BBA) - Reviews on Cancer 1845.2 (2014): 136-54

And, considering that the leaf of Nicotiana tabacum, the tobacco plant most often used to make cigarettes, contains about 20000 parts per million of nicotine, it's very possible to feel some of these effects if you smoke enough

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