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This process is driven by the accumulation of ROS and the peroxidation of polyunsaturated fatty acids in cellular membranes, leading to the formation of lipid hydroperoxides that compromise membrane integrity and cause cell swelling and death

In this study, FKB targeted TLR2 to inhibit the formation of the TLR2-MyD88 complex, thereby suppressing the NF-B signaling pathway both in vivo and in vitro

Several drugs that target mGluRs are used to restore the excitation and inhibition balance in brain cortical regions

Downregulation of miR-30e was found in substantia nigra pars compacta (SNpc) of MPTP-induced PD animal model

No FDA-approved human dose exists for either peptide, so there is no correct dose to state only what investigators used under monitoring