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In the central nervous system of vertebrates and invertebrates, there is a system of glutamatergic neurons: descending pathways emanating from cortical and hippocampal pyramidal cells

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3.3 Mechanical stress and ECM remodeling Throughout the initiation and progression of pulmonary fibrosis, mechanical stressan essential exogenous biophysical cueis regarded as a pivotal regulator of epithelial-to-mesenchymal transition (EMT) and fibrotic tissue expansion ( Experimental data demonstrate that sustained mechanical stretch activates the TGF-/Smad axis, suppresses E-cadherin, and elevates mesenchymal markers such as Vimentin and Snail, thereby driving alveolar epithelial cells toward a mesenchymal phenotype