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found that in amyotrophic lateral sclerosis, the 43 kDa TAR DNA-binding protein, a marker protein, can lead to mPTP opening and mtDNA release into mitochondria

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Similarly, extract has also demonstrated the ability to reverse or mitigate tissue alterations caused by toxic agents and oxidative stress, by modulating the histological organization and redox biology in testicular and liver tissues of rodents [46]