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Cholesterol accumulation can also lead to demyelination, as seen in Cerebrotendinous Xanthomatosis, caused by mutations in the sterol 27-hydroxylase gene ( CYP27A1 ) 129,130

fibrillar aggregation The structure of S suggests that transient Smembrane interactions could be stabilized biochemically by either amplifying the electrostatic interaction between positive lysines in S and negative lipid head groups (e.g., via the engineered 3K S mutant) or by increasing the hydrophobicity in the lower, membrane-inserted half of the S amphipathic helix (e.g., via the engineered KLK S mutant) (Fig

10.7759/cureus.27666 28 CarolaC.SalazarA.RakersC.HimbertF.DoQ.-T.BernardP.et al (2021)

10.1194/jlr.M002808 63 YangW