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The complementary mechanisms of amylin and GLP-1 pathways have generated significant scientific interest, with researchers exploring whether combined receptor activation produces synergistic improvements in weight and metabolic outcomes

Similar results were observed in another clinical study, in which depressed patients showed increased hsa-miR-342 and reduced hsa-miR-146a and hsa-miR-155 levels in peripheral blood mononuclear cells, with a positive correlation between hsa-miR-342 and TNF- levels ( In an experimental study, a chronic social stress animal model induced depressive-like behaviors in mice and significantly reduced miR-184-3p levels in the neurons of the PVN (Xu et al., 2024)

Schematic representation on regulation of ITCs to control the tumor growth via NF-B has been demonstrated in Figure 4

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Challenges in the therapy of NeuroHIV As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of HIV-1 provirus in both T-cell reservoirs and non-CD4 T-cell reservoirs, there is a critical need to develop new brain-penetrating agents that can effectively target both CNS and peripheral immune cells to simultaneously silence HIV-1 and reduce the risk of neuroinflammation