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Burrage EN, Coblentz T, Prabhu SS, Childers R et al (2023) Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment

4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)

Consistent use is usually required for visible results

Is erectile dysfunction the 'tip of the iceberg' of a systemic vascular disorder

J., Pyo J