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Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S , Futreal A, Wang YA, Kwong LN, DePinho RA

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Disclosures: Dilara Turan Gokce: Nothing to Disclose, Derya Ari: Nothing to Disclose, Ilkay Idilman: Nothing to Disclose, Meral Akdogan: Nothing to Disclose 2055 DELETION OF ETS1 IN HEPATIC STELLATE CELLS ACCELERATES DEVELOPMENT OF LIVER FIBROSIS Wonseok Lee 1 Xiao Liu 1 Hyun Young Kim 1 Karin Diggle 1 David Brenner 2 Tatiana Kisseleva 1 , 1 University of California, San Diego, 2 Sanford Burnham Prebys Medical Discovery Institute Background: In response to chronic liver injury, quiescent Hepatic Stellate Cells (HSCs) activate into Collagen Type-I-producing myofibroblasts (activated HSCs), leading to the development of hepatic fibrosis

A small number of double-blind, placebo-controlled clinical trials, with a degree of variability in enrollment criteria, intervention, and outcome measures, have been conducted to test whether additional antibiotics are effective (80, 83, 135, 154, 155)