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Hepatic stellate cells promote hepatocellular carcinoma development by regulating histone lactylation: Novel insights from single-cell RNA sequencing and spatial transcriptomics analyses

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Focussing on glutathione-dependent redox modifications, we screened the literature for target thiols of S -glutathionylation, and found that 151 plastid proteins have been identified as glutathionylation targets, while the exact cysteine residue is only known for 17% (26 proteins), with one or multiple sites per protein, resulting in 37 known S -glutathionylation sites for plastids

Conclusion The concept of glutamine as a conditionally indispensible amino acid is dead, as is the concept of supplementing all critically ill patients