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doi: 10.3389/fimmu.2022.1007165

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The most abundant free radical scavenger synthesized in humans, there is a wealth of evidence which demonstrates glutathione's status to be significant in a number of acute and chronic diseases

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Pyruvate kinase M2 is requisite for T h 1 and T h 17 differentiation

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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

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