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Smoking also reduces saliva production that normally helps neutralize refluxed acid and clear it back to the stomach

Additionally, the secoiridoid metabolite is chemically reactive, capable of engaging in various reactions like oxidation-reduction, which may underlie its pharmacological effects

This recent scientific update notes clinical evidence of effects from cruciferous vegetables (in combination, and specifically watercress, garden cress, and broccoli), allium vegetables, apiaceous vegetables, grapefruit, resveratrol, fish oil, quercetin, daidzein, and lycopene

However, the relevant mechanism is still unclear, and a large number of animal experiments and clinical trials are needed

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