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Hence, it was postulated that the brain drives these psychiatric comorbidities seen in IBS patients, which leads to the conclusion that IBS is a primary brain disorder or somatic symptom disorder whereby the brain is involved in manifesting the gastrointestinal symptoms (Tanaka et al., 2011

Stanton adds, and it's treated with a specific type of antibiotic

Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox)

Front Physiol 8:691 Samra K, Singer M, Dyson A (2019) Hydrogen selenide as the 4th gasotransmitter: a metabolic modulator with potential therapeutic utility in acute/critical illness states

Chaudhry KK, Shukla PK, Mir H, Manda B, Gangwar R, Yadav N, McMullen M, Nagy LE, Rao R