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Extraintestinally, CD can cause neurological and dermatological manifestations, as well as systemic effects like neurodegenerative diseases, certain lymphomas, fatigue, and headaches (Bonner et al, 2025)

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"Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial"

When treated with trazodone, depressive episodes can range from manic depression to manic psychosis

When youre deficient in B12, not only do the nerves suffer but the body also struggles to produce sufficient healthy red blood cells to carry oxygen to tissues and nerves, compounding the problem and often leading to anemia