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(2) Clinical design deficiencies: most human trials utilize berberine chloride formulations not optimized for obesity-specific indications, coupled with inadequate endpoint selection targeting adiposity pathophysiology

[DOI] [PubMed] [Google Scholar] 62.Fenech M

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To analyze the anti-inflammatory effects of GBP@HA NPs in vivo, we examined the inflammation-related factors MPO, TNF-, IL-6, IL-1, and IL-10 in mouse colons (Fig