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An important challenge for future studies will be to define which nodes within this multilayered GSH-centered defense network represent true therapeutic vulnerabilities across different tissue and tumor contexts

doi: 10.1111/1541-4337.12249 258 SinghASinghJKaurSGunjalMKaurJNandaVet al

Various metabolic parameters, including body composition, liver function, lipid and glucose metabolism, were measured

Academic and industrial efforts have progressively advanced from single-tissue to multi-tissue and multi-organ OoC systems, converging toward autologous OoC (aOoC) platforms that can (i) capture patient-specific immunopathophysiology with higher fidelity, (ii) potentially complement and, in specific contexts, reduce reliance on animal models, and (iii) directly inform immunotherapy development and therapeutic decision-making within precision medicine

Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy