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This represents genuine disease prevention rather than simply managing existing pathology

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In the OASIS-1 study, 13% of participants (people with obesity without diabetes) receiving oral semaglutide 50 mg experienced altered skin sensation events compared to 1% with placebo - these events were generally mild to moderate in severity, occurred during dose escalation to the higher doses and resolved without requiring permanent treatment discontinuation [21]

Obesity: a chronic relapsing progressive disease process

Every cross-compound number below is therefore a cross-trial inference, not a direct result