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222 In addition, the overexpression of other components of the -secretase complex, including nicastrin, anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (Pen 2), also suppresses p53 expression in AD animal models

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Lowering protein by an average of 0.72 grams per kilogram of body weight per day resulted in an average decrease of 25% in IGF-1 (30)