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COVID-19 neurotropism and PD: exploring the links The CNS has been disrupted by COVID-19 in a variety of ways, including direct SARS-CoV-2 invasion of neuronal cells, huge inflammatory elements driven by severe systemic inflammation flowing into brains, respiratory failure linked brain ischemia, etc [18,19,20]

Western blotting analysis of the top-ranked inflammatory pathways (NF-B and MAPK) revealed that LPS stimulation markedly upregulated phosphorylated P65 (p-P65, NF-B pathway) and phosphorylated ERK (p-ERK, MAPK pathway), whereas Se/LDH@PEG-M treatment significantly suppressed their activation (Fig